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Toshikazu Yoshikawa Selected Research

rebamipide

12/2012Rebamipide ameliorates indomethacin-induced small intestinal injury in rats via the inhibition of matrix metalloproteinases activity.
9/2011Rebamipide promotes healing of colonic ulceration through enhanced epithelial restitution.
12/2010Management of recurrence of symptoms of gastroesophageal reflux disease: synergistic effect of rebamipide with 15 mg lansoprazole.
6/2010Rebamipide: a gastrointestinal protective drug with pleiotropic activities.
3/2008Prophylactic effect of rebamipide on aspirin-induced gastric lesions and disruption of tight junctional protein zonula occludens-1 distribution.
8/2007Rebamipide, a gastro-protective and anti-inflammatory drug, promotes gastric ulcer healing following eradication therapy for Helicobacter pylori in a Japanese population: a randomized, double-blind, placebo-controlled trial.
1/2006A pilot study to evaluate a new combination therapy for gastric ulcer: Helicobacter pylori eradication therapy followed by gastroprotective treatment with rebamipide.
10/200515th anniversary of rebamipide: looking ahead to the new mechanisms and new applications.
10/2005Prevention by rebamipide of acute reflux esophagitis in rats.

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Toshikazu Yoshikawa Research Topics

Disease

80Inflammation (Inflammations)
10/2016 - 01/2002
43Neoplasms (Cancer)
08/2015 - 11/2002
41Type 2 Diabetes Mellitus (MODY)
01/2016 - 01/2002
29Colitis
10/2016 - 01/2002
25Insulin Resistance
01/2016 - 01/2004
24Ischemia
03/2011 - 01/2002
17Ulcer
01/2015 - 09/2005
16Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
10/2016 - 01/2002
15Stomach Neoplasms (Stomach Cancer)
01/2014 - 01/2002
14Fibrosis (Cirrhosis)
09/2015 - 05/2007
14Atherosclerosis
05/2013 - 05/2002
14Infections
04/2013 - 08/2002
13Non-alcoholic Fatty Liver Disease
09/2015 - 04/2008
13Hemorrhage
05/2014 - 05/2002
13Pneumonia (Pneumonitis)
01/2009 - 05/2002
12Carcinogenesis
01/2018 - 01/2002
12Hepatocellular Carcinoma (Hepatoma)
10/2013 - 11/2005
12Reperfusion Injury
03/2011 - 01/2002
12Acute Lung Injury
11/2008 - 12/2002
10Stomach Ulcer (Gastric Ulcer)
10/2016 - 09/2005
10Body Weight (Weight, Body)
01/2016 - 01/2002
10Colonic Neoplasms (Colon Cancer)
06/2013 - 01/2003
10Ulcerative Colitis
05/2012 - 06/2002
9Rheumatoid Arthritis
07/2013 - 07/2003
9Cardiovascular Diseases (Cardiovascular Disease)
12/2008 - 06/2003
8Wounds and Injuries (Trauma)
12/2012 - 10/2005
8Hyperthermia
01/2012 - 11/2002
8Disseminated Intravascular Coagulation
10/2011 - 06/2003
8Hypoxia (Hypoxemia)
06/2010 - 06/2003
8Obesity
01/2010 - 10/2003
8Lung Injury
04/2007 - 04/2002
7Fatty Liver
01/2016 - 04/2008
7Neoplasm Metastasis (Metastasis)
03/2009 - 01/2003
6Carcinoma (Carcinomatosis)
07/2011 - 11/2002
6Pancreatitis
07/2009 - 03/2005
6Diabetic Nephropathies (Diabetic Nephropathy)
04/2008 - 09/2002
6Endometriosis
10/2006 - 01/2002
5Alcoholic Fatty Liver
09/2015 - 03/2009
5Pain (Aches)
08/2013 - 06/2011
5Arthritis (Polyarthritis)
07/2013 - 08/2002
5Metabolic Syndrome (Dysmetabolic Syndrome X)
04/2013 - 03/2007
5Chronic Hepatitis C
12/2011 - 06/2010

Drug/Important Bio-Agent (IBA)

47CytokinesIBA
09/2013 - 01/2002
39Proteins (Proteins, Gene)FDA Link
10/2016 - 01/2002
24Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
03/2011 - 01/2002
23LipopolysaccharidesIBA
03/2011 - 12/2002
17Pharmaceutical PreparationsIBA
01/2014 - 01/2002
17Reactive Oxygen Species (Oxygen Radicals)IBA
01/2011 - 04/2002
16DNA (Deoxyribonucleic Acid)IBA
01/2015 - 11/2003
15Messenger RNA (mRNA)IBA
10/2016 - 01/2002
15Vehicle Emissions (Emissions, Vehicle)IBA
02/2009 - 04/2002
141-(2-(dodecyloxy)ethyl)pyrrolidine hydrochloride (DEP)IBA
02/2009 - 04/2002
13Sulfonic AcidsIBA
10/2016 - 03/2006
13Interleukin-6 (Interleukin 6)IBA
02/2012 - 06/2002
13NF-kappa B (NF-kB)IBA
06/2009 - 01/2002
12LipidsIBA
09/2015 - 06/2003
12Indomethacin (Indometacin)FDA LinkGeneric
02/2014 - 01/2006
12Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
02/2014 - 12/2002
12EndotoxinsIBA
09/2007 - 05/2002
11Biomarkers (Surrogate Marker)IBA
01/2016 - 04/2002
11Dextran SulfateIBA
09/2013 - 01/2002
11LigandsIBA
03/2011 - 01/2002
10Peroxidase (Myeloperoxidase)IBA
10/2016 - 04/2004
10Glucose (Dextrose)FDA LinkGeneric
01/2016 - 01/2004
10AntioxidantsIBA
01/2010 - 05/2002
9Transcription Factors (Transcription Factor)IBA
01/2018 - 04/2003
9Carbon MonoxideIBA
04/2016 - 04/2009
9Insulin (Novolin)FDA Link
01/2016 - 09/2004
9rebamipideIBA
12/2012 - 10/2005
9AlbuminsIBA
09/2009 - 01/2004
9Testosterone (Sustanon)FDA Link
12/2008 - 06/2003
8AntigensIBA
08/2015 - 11/2002
8Thiobarbituric Acid Reactive SubstancesIBA
01/2014 - 04/2004
8Vitamin EFDA LinkGeneric
09/2013 - 05/2002
8Free RadicalsIBA
06/2012 - 01/2002
8Hemoglobins (Hemoglobin)IBA
04/2012 - 05/2003
8PPAR gammaIBA
02/2010 - 01/2002
8Nitric Oxide (Nitrogen Monoxide)FDA Link
06/2009 - 01/2002
8Interleukin-8 (Interleukin 8)IBA
12/2008 - 01/2002
8ChemokinesIBA
11/2006 - 05/2002
7Phenobarbital (Luminal)FDA Link
10/2016 - 01/2002
7Chemotactic FactorsIBA
09/2012 - 04/2004
7Serine Proteinase Inhibitors (Serine Protease Inhibitors)IBA
02/2010 - 03/2005
7Oxygen (Dioxygen)IBA
04/2007 - 01/2002
6Alanine Transaminase (SGPT)IBA
09/2015 - 03/2010
6InterferonsIBA
09/2013 - 04/2010
6OligonucleotidesIBA
06/2013 - 01/2004
6Dextrans (Dextran)FDA Link
05/2012 - 08/2004
6sodium sulfate (sodium bisulfate)FDA LinkGeneric
05/2012 - 08/2004
6Dehydroepiandrosterone (DHEA)IBA
09/2010 - 12/2004
6urinastatin (MR 20)IBA
07/2009 - 03/2005
6InterleukinsIBA
01/2008 - 11/2002
5Rabeprazole (Aciphex)FDA Link
07/2014 - 09/2005
5Heme Oxygenase-1IBA
08/2013 - 12/2008
5AdiponectinIBA
04/2013 - 09/2004

Therapy/Procedure

46Therapeutics
10/2016 - 01/2002
8Drug Therapy (Chemotherapy)
11/2010 - 07/2004
7Oral Administration
10/2016 - 11/2002
7Glycemic Control
06/2010 - 12/2004
5Enema (Enemas)
06/2014 - 03/2006